Cyclic ADP-Ribose and NAADP: Structures, Metabolism and FunctionsSpringer Science & Business Media, 6 de des. 2012 - 460 pàgines In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems. |
Continguts
7 | |
8 | |
Ca2+ Mobilization by cADPR and NAADP | 13 |
45 | 19 |
ADPRibosyl Cyclases A Family of cADPR and NAADP | 23 |
Structure of the Aplysia ADPRibosyl Cyclase | 29 |
55595 | 38 |
Regulation of Synthesis of cADPR and NAADP | 44 |
Role of CD38 as a Catalytically Active Transporter of cADPR | 247 |
Paracrine | 253 |
Interactions between CD38 Rat Astrocytes and Hippocampal | 261 |
The CD38Cyclic ADPRibose Signal System in Pancreatic | 269 |
CD38 as a Major Enzyme for cADPR Metabolism in Mammalian | 275 |
CD38 Knockout Mice | 280 |
NAD Metabolism in BetaCells and Concluding Remarks | 289 |
The Role of CADPR and NAADP in T Cell Calcium Signaling | 300 |
CAMP Interactions with CADPR Signaling Pathways | 51 |
References | 59 |
A Natural History of the Human CD38 Gene | 65 |
A Yeast Expression System | 81 |
The pYEXCD157 Clone | 87 |
Expression of Recombinant Proteins in Shaker Cultures | 93 |
Novel Cycling Assays for CADPR and NAADP | 100 |
Procedures for Measuring Endogenous Levels of CADPR | 107 |
Purification of NMNAT | 113 |
Removal of Nucleotides Interfering with the NAADP Assay | 115 |
Pharmacology of Cyclic ADPRibose and NAADP | 121 |
CADPR Analogs with NRibosyl Modifications | 128 |
68 | 129 |
NAADP Analogs with the Adenine Modified | 134 |
71 | 140 |
Separate but Interacting Calcium Stores | 141 |
Mechanisms of Ca2+ Mobilization Mediated by CADPR and NAADP | 147 |
Ca2+ Mobilization and Influx | 153 |
Multiple Ca2+ Stores and Specificity | 155 |
Sensitizing CalciumInduced Calcium Release | 167 |
Intercellular Messages | 173 |
Sulfhydryl Agents and CICR | 179 |
CADPRInduced Ca2+ Release Upstream of Other Channels | 185 |
Spatial and Temporal Control of Calcium Signaling by NAADP | 199 |
NAADPMediated Ca²+ Waves | 203 |
Oscillations Require Functional CICR Pathways | 209 |
Regulation of Immune Responses by CD38 and cADPR | 216 |
CD38 and CADPR Regulate Intracellular Free Calcium Levels | 225 |
Does CD38 Catalyzed ADPR or NAADP Influence Calcium | 232 |
References | 234 |
75 | 238 |
A New Way for Regulating Intracellular Calcium | 241 |
The Receptor for CADPR | 307 |
Conclusion | 313 |
Calcium Signaling by CADPR in Cardiac Myocytes | 319 |
The Importance of Temperature for the Actions of cADPR in | 325 |
Regulation of SR Calcium Sequestration by cADPR | 331 |
Conclusions | 338 |
Enzymatic Pathway of cADPR Production and Metabolism | 345 |
CADPR in Vasoconstrictor Response to Agonists | 351 |
Acknowledgments | 357 |
Pancreatic Acinar Cells | 364 |
Calcium and CalciumLinked Second Messengers are Main | 381 |
ADPRibosylation and CD38 Signaling | 397 |
Cells and Pancreatic Islet Cells 405 Acknowledgments 405 References | 405 |
RetinoidMediated Signaling and CD38 Expression Mehta K Houston USA 409 Introduction | 408 |
Retinoids as Modulators of Transcription | 411 |
RetinoidMediated Regulation of CD38 Expression | 414 |
Other Modulators of CD38 Expression | 418 |
Clinical Implications of RetinoidInduced CD38 Expression 419 RetinoidInduced CD38 Expression and Retinoic Acid Syndrome | 419 |
RetinoidInduced CD38 as Target for Immunotherapy | 421 |
Conclusion | 422 |
423 | |
Calcium Regulation in Smooth Muscle Through the CD38Cyclic ADPRibose Pathway White TA Deshpande DA Dogan S Panettieri RA Walseth TF a... | 427 |
CADPR Metabolism in Smooth Muscle | 428 |
Role of cADPR in Ca2+ Regulation in Smooth Muscle | 432 |
Regulation of CD38cADPR Pathway in Smooth Muscle | 436 |
Regulation of CADPR Induced Ca2+ Release | 441 |
Acknowledgements | 443 |
444 | |
450 | |
453 | |
Altres edicions - Mostra-ho tot
Cyclic ADP-Ribose and NAADP: Structures, Metabolism, and Functions Hon Cheung Lee Previsualització limitada - 2002 |
Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions Hon Cheung Lee Previsualització no disponible - 2012 |
Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions Hon Cheung Lee Previsualització no disponible - 2011 |
Frases i termes més freqüents
Aarhus acid adenine dinucleotide acinar cells adenine adenine dinucleotide phosphate ADP-ribosyl cyclase activity ADPR agonist analogs antagonist antigen Aplysia binding Biochem Biol Biophys Ca² Ca2+ mobilization Ca2+ release Ca2+ signaling Ca2+ stores Ca2+ waves CADPR CADPR and NAADP CADPR levels calcium signaling calmodulin cardiac catalyzed Chem CICR concentrations cyclic ADP cyclic ADP-ribose cycling assay cytosolic effects egg homogenates endogenous enzyme fluorescence fMLP function Galione gene human CD38 hydrolysis Immunol increase induced influx inhibition inositol trisphosphate insulin secretion intracellular intracellular Ca2+ islets kinase Lee HC lymphocytes mechanism mediated metabolism metabolite mice microsomes modulation molecule myocytes NAADP NADP neutrophils nicotinic acid adenine NMN-AT nucleotide Okamoto H oocytes pancreatic acinar cells pathway Physiol production protein regulation release channels response reticulum ribose role ryanodine receptor sarcoplasmic reticulum sea urchin sea urchin eggs second messenger sensitive smooth muscle starfish oocytes stimulation substrate synthesis Takasawa tissues trigger Walseth TF yeast Zocchi