Biochemistry of Lipids, Lipoproteins and Membranes
Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.
* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs.
* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.
* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry.
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Chapter 3 Fatty acid and phospholipid metabolism in prokaryotes
Chapter 4 Lipid metabolism in plants
Chapter 5 Oxidation of fatty acids in eukaryotes
Chapter 6 Fatty acid synthesis in eukaryotes
Chapter 7 Fatty acid desaturation and chain elongation in mammals
Chapter 8 Phospholipid biosynthesis in eukaryotes
Chapter 9 Etherlinked lipids and their bioactive species
Chapter 14 Cholesterol biosynthesis
Chapter 15 Metabolism and function of bile acids
Chapter 16 Lipid assembly into cell membranes
Chapter 17 Lipoprotein structure
Chapter 18 Assembly and secretion of triacylglycerolrich lipoproteins
Chapter 19 Dynamics of lipoprotein transport in the circulatory system
Chapter 20 Lipoprotein receptors
Chapter 21 Lipids and atherosclerosis
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acetyl-CoA activity acyl chains acyl-CoA acyltransferase adipocytes adipose amino acid apo A1 apolipoproteins bacteria bilayer bile acids binding Biochem Biol biosynthesis catalyzed cells cellular ceramide Chapter cholesterol choline chylomicrons cloned coli complex contain cytoplasmic cytosolic degradation dehydrogenase desaturase domain encoding enzyme esters ethanolamine ether eukaryotic expression fatty acid synthesis function gene genetic glycerolipids glycosphingolipids Golgi HMG-CoA reductase human hydrolysis hydrophobic increased inhibition insulin interaction intracellular involved isoforms kinase LDL receptor lesions levels ligand lipase lipid lipolysis lipoproteins liver long-chain macrophages malonyl-CoA mammalian mechanism membrane proteins metabolism mice mitochondria moiety molecular molecules mRNA mutants N-terminal oxidation oxysterols particles pathway peroxisomal phosphatidic phosphatidylcholine phospholipids phosphorylation plants plasma membrane plasmalogens PPAR precursor production protein reaction regulation residues role secretion sequence signaling specific sphingolipids SREBP SREBP-1c sterol structure substrate subunit surface synthase tissues transcription factors transfer translocation transport triacylglycerol vivo VLDL yeast
Pàgina 577 - Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 1988;7:411927.
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