Biochemistry of Lipids, Lipoproteins and Membranes

Neale Ridgway, Roger McLeod
Elsevier, 14 de març 2008 - 624 pàgines
3 Ressenyes
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Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.
  • Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs
  • Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances
  • Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry

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Chapter 2 Lipid modifications of proteins
Chapter 3 Fatty acid and phospholipid metabolism in prokaryotes
Chapter 4 Lipid metabolism in plants
Chapter 5 Oxidation of fatty acids in eukaryotes
Chapter 6 Fatty acid synthesis in eukaryotes
Chapter 7 Fatty acid desaturation and chain elongation in mammals
Chapter 8 Phospholipid biosynthesis in eukaryotes
Chapter 9 Etherlinked lipids and their bioactive species
Chapter 14 Cholesterol biosynthesis
Chapter 15 Metabolism and function of bile acids
Chapter 16 Lipid assembly into cell membranes
Chapter 17 Lipoprotein structure
Chapter 18 Assembly and secretion of triacylglycerolrich lipoproteins
Chapter 19 Dynamics of lipoprotein transport in the circulatory system
Chapter 20 Lipoprotein receptors
Chapter 21 Lipids and atherosclerosis

Chapter 10 Lipid metabolism in adipose tissue
Chapter 11 Phospholipases
cyclooxygenase lipoxygenase and epoxygenase pathways
Chapter 13 Sphingolipids
Subject index
Color plate section

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Pàgina 577 - Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 1988;7:411927.
Pàgina 577 - Davis, CG, Elhammer, A., Russell, DW, Schneider, WJ, Kornfeld, S., Brown, MS and Goldstein, JL (1986) J. Biol . Chem. 261: 2828-2838.
Pàgina 577 - WJ (1985) Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol 1, 1-39 42.

Sobre l'autor (2008)

Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body – cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer’s, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements.

Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body – and how different fats can either lead to, or prevent, chronic disease. He’s particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.

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