Introduction to the Blood-Brain Barrier: Methodology, Biology and PathologyWilliam M. Pardridge Cambridge University Press, 28 d’ag. 1998 - 486 pàgines The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities. |
Continguts
List of contributors | 1 |
N JOAN ABBOTT HANNELORE BAUER ULRICH BICKEL | 2 |
EAIN M CORNFORD | 11 |
rue Méchain 59019 Lille Cedex | 22 |
TETSUYA TERASAKI | 24 |
DAVID J BEGLEY | 32 |
LISE PRESCOTT USA SHOICHIRO TSUKITA | 36 |
ULRICH BICKEL | 41 |
LAURENCE FENART BÉNÉDICTE DEHOUCK MARIEPIERRE DEHOUCK | 221 |
AKIRA TSUJI and IKUMI TAMAI | 238 |
MALCOLM SEGAL | 251 |
CONRAD E JOHANSON | 259 |
LISE PRESCOTT and MILTON W BRIGHTMAN | 270 |
N R SAUNDERS and K M DZIEGIELEWSKA | 277 |
LEE L RUBIN LOUISE MORGAN and JAMES M STADDON | 293 |
R BÉLIVEAU m demeule e BEAULIEU and L JETTÉ | 301 |
WILLIAM M PARDRIDGE | 49 |
DARRYL R PETERSON and RICHARD A HAWKINS | 62 |
HEINZ GÖGELEIN RÜDIGER POPP and JOACHIM HOYER | 71 |
CARSTEN T BEUCKMANN and HANSJOACHIM GALLA | 79 |
KENNETH L AUDUS JAYNA M ROSE WEN WANG | 86 |
ROMÉO CECHELLI INSERM U325 USC School of Medicine | 96 |
SUKRITI NAG | 113 |
ROUMEN BALABANOV Université du Québec à Montréal Department of Molecular Biology | 121 |
JOSEPH FENSTERMACHER and LING WEI | 122 |
GITTE M KNUDSEN and OLAF B PAULSON | 133 |
SUNGCHENG HUANG CARL HOH JORGE R BARRIO | 140 |
CLIVE P HAWKINS | 147 |
LESTER R DREWES | 165 |
N R SAUNDERS Canada France | 170 |
HANNELORE BAUER | 175 |
QUENTIN R SMITH and JAMES STOLL | 188 |
P BORST and A H SCHINKEL | 198 |
MALCOLM SEGAL Japan | 205 |
RICHARD F KEEP STEVEN R ENNIS and A LORRIS BETZ | 207 |
CHRISTIAN FRELIN and PAUL VIGNE | 214 |
JEANMARIE BOURRE | 308 |
BÜRKHARD SCHLOSSHAUER | 314 |
SHOICHIRO TSUKITA MIKIO FURUSE and MASAHIKO ITOH | 322 |
R E CATALÁN | 330 |
SYLVIE M CAZAUBON and PIERRE Oliver COURAUD | 338 |
N JOAN ABBOTT | 345 |
ROUMEN BALABANOV and PAULA DOREDUFFY | 354 |
CORNFORD Department of Neurology MIKIO FURUSE | 372 |
HARRY V VINTERS | 379 |
CELIA F BROSNAN and LUZ CLAUDIO | 386 |
MARK FISHER | 401 |
HENRYK M WISNIEWSKI and ALBERT S LOSSINSKY | 409 |
CAROL K PETITO | 419 |
Wayne State University School of CP 8888 succursale Centreville 1066 CX Amsterdam | 421 |
BARBRO B JOHANSSON | 427 |
P A STEWART and D MIKULIS | 434 |
JOHN T POVLISHOCK | 441 |
GARETH TURNER | 454 |
JAAKKO PARKKINEN | 462 |
Altres edicions - Mostra-ho tot
Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology William M. Pardridge Previsualització limitada - 1998 |
Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology William M. Pardridge Previsualització no disponible - 2006 |
Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology William M. Pardridge Previsualització no disponible - 2006 |
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abluminal membrane Acta activity albumin amino acid amino acid transport analysis antibody antigen arachnoid arterial astrocytes BBB permeability BBB transport BCEC Betz binding Biochem Biol blood-brain barrier BMECs brain capillary endothelial brain endothelial brain microvessels Brain Res brain uptake Ca2+ capillary endothelial cells cDNA cellular cerebral cerebrospinal fluid channels Chem choroid plexus cloning compound concentration Cornford cultured cytokines dialysis diffusion drugs efflux endothelial cells endothelium experimental expression extracellular factors fatty acids fluid function gene glucose transporter Glut GLUT1 human brain hypertension immunoreactive increased inhibitors injection isolated brain capillaries kinetics measured mechanisms mediated metabolism method microdialysis microvascular molecular molecules mouse mRNA Neurochem neurons Neuropathol Neurosci neutral amino acid Oldendorf P-glycoprotein P-gp peptides perfusion pericytes Pharmacol Physiol plasma membrane probe protein rat brain receptor regulation studies substrate technique tight junctions tion tracer transferrin vascular vesicles vessels vitro vivo