Hematopoietic Stem Cell DevelopmentIsabelle Godin, Ana Cumano Springer Science & Business Media, 27 de maig 2010 - 178 pàgines Hematopoietic Stem Cells brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models. Thus, this book allows a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing the conserved trends in development. This book culminates with state-of –the art knowledge on hematopoietic development in human species and discussions of the most recent breakthroughs with relevance to both researchers and clinicians. |
Continguts
1 | |
CHAPTER 2 Genetic Dissection of Hematopoiesis Using the Zehrafish | 14 |
CHAPTER 3 Extra and Intraembryonic HSC Commitment in the Avian Model | 32 |
CHAPTER 4 Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation | 46 |
CHAPTER 5 Yolk Sac Development in Mice | 62 |
CHAPTER 6 LongTerm Reconstituting Hematopoietic Stem Cell Capacity in the Embryo | 72 |
The Cradle of Definitive Hematopoiesis? | 80 |
CHAPTER 8 Endothelial and Hematopoietic Cells in the Intraembryonic Compartment | 92 |
CHAPTER 9 Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo | 108 |
A Parallel with Vertebrates | 124 |
Expression Analysis | 142 |
CHAPTER 12 Gene and Cell Therapy Involving Hematopoietic Stem Cell | 154 |
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Acad Sci USA adult AGM region Aiolos AML1 angioblasts angiogenesis aortic avian blastomeres blood cells blood islands blood vessels bone marrow cell development chick circulation Cumano defects definitive hematopoiesis Dev Biol Development 1999 developmental Dieterlen-Lievre differentiation donor dorsal aorta Drosophila early embryo embryo proper embryogenesis endoderm endothelial cells endothelium engraftment erythrocytes erythroid erythropoiesis fetal liver Flk1 formation function gastrulation genetic Godin hemangioblast hemato hematopoietic and endothelial hematopoietic cells hematopoietic clusters hematopoietic lineages hematopoietic precursors hematopoietic progenitors hematopoietic stem cells hemocyte hemogenic HSCT human Ikaros Immunity Immunol intra-aortic intraembryonic larvae Lmo2 lymphocytes lymphoid macrophages mammalian markers marrow transplantation mesoderm mice migration molecular mouse embryo multipotent murine mutants myeloid Natl Acad Sci ontogeny P-Sp pathway phenotype primitive Proc Natl Acad progenitor cells proliferation protein receptor repopulating role Runx1 signaling stage studies tissues transcription factors vascular vasculogenesis VEGF vertebrate vitro vivo Xenopus yolk sac zebrafish