The Genetic Basis of Human CancerMcGraw Hill Professional, 2002 - 821 pàgines This book provides a state-of-the-art overview of the fundamentals of genetics and human phenotypes, gene mutation, the Human Genome Project, and genetic imprinting. Coverage of current clinical aspects and im plications for diagnosis and treatment on a wide spectrum of active ca ncer research is also included. Thoroughly revised and updated this e dition includes two new chapters on Peutz-Jaeghers and Juvenile polypo sis syndromes. |
Continguts
The Nature and Mechanisms of Human Gene Mutation | 7 |
Genomic Imprinting and Cancer | 43 |
Hepatocellular Carcinoma 741 | 49 |
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The Genetic Basis of Human Cancer Bert Vogelstein,Kenneth W. Kinzler Previsualització no disponible - 1998 |
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A-T patients abnormalities Acad Sci USA activity acute lymphoblastic leukemia allele amino acid amplification analysis apoptosis associated ataxia-telangiectasia binding Blood breakpoints c-myc Cancer Res carcinoma cDNA cell cycle cell lines cellular chromosomal translocations clinical cloning codon colorectal cancer complex cyclin cytogenetic defect deletion disease domain encodes exon Fanconi anemia frequency function fusion gene fusion protein gene expression Gene fusion genomic imprinting growth factor helicase hematopoietic HNPCC homologous Hum Genet identified IGF2 inactivation instability interaction involved lesion locus lymphoma malignant mammalian maternal mechanism methylation mice Mol Cell Biol molecular motif mRNA mutations MYCN Natl Acad Sci neuroblastoma normal nuclear nucleotide oncogene pathway percent phenotype phosphorylation Proc Natl Acad proto-oncogene rearrangements receptor recombination region regulation replication result role signal somatic specific splice studies syndrome T-cell target transcription factor transformation tumor suppressor tumor-suppressor genes tumors tyrosine kinase xeroderma pigmentosum yeast
Referències a aquest llibre
Dynamics of Cancer: Incidence, Inheritance, and Evolution Steven A. Frank Previsualització limitada - 2007 |